@article {Ash1071, author = {Samuel Y Ash and Rola Harmouche and Rachel K Putman and James C Ross and Fernando J Martinez and Augustine M Choi and Russell P Bowler and Elizabeth A Regan and Jeffrey L Curtis and MeiLan K Han and Richard C Boucher and Wanda K O{\textquoteright}Neal and Hiroto Hatabu and David A Lynch and Ivan O Rosas and Gary M Hunninghake and Raul San Jose Estepar and George R Washko}, editor = {,}, title = {Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers}, volume = {73}, number = {11}, pages = {1071--1074}, year = {2018}, doi = {10.1136/thoraxjnl-2017-211208}, publisher = {BMJ Publishing Group Ltd}, abstract = {A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61\% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40\% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.}, issn = {0040-6376}, URL = {https://thorax.bmj.com/content/73/11/1071}, eprint = {https://thorax.bmj.com/content/73/11/1071.full.pdf}, journal = {Thorax} }