TY - JOUR T1 - Disagreement of diameter and volume measurements for pulmonary nodule size estimation in CT lung cancer screening JF - Thorax JO - Thorax SP - 779 LP - 781 DO - 10.1136/thoraxjnl-2017-210770 VL - 73 IS - 8 AU - Marjolein A Heuvelmans AU - Joan E Walter AU - Rozemarijn Vliegenthart AU - Peter M A van Ooijen AU - Geertruida H De Bock AU - Harry J de Koning AU - Matthijs Oudkerk Y1 - 2018/08/01 UR - http://thorax.bmj.com/content/73/8/779.abstract N2 - We studied 2240 indeterminate solid nodules (volume 50–500mm3) to determine the correlation of diameter and semi-automated volume measurements for pulmonary nodule size estimation. Intra-nodular diameter variation, defined as maximum minus minimum diameter through the nodule’s center, varied by 2.8 mm (median, IQR:2.2–3.7 mm), so above the 1.5 mm cutoff for nodule growth used in Lung CT Screening Reporting and Data System (Lung-RADS). Using mean or maximum axial diameter to assess nodule volume led to a substantial mean overestimation of nodule volume of 47.2% and 85.1%, respectively, compared to semi-automated volume. Thus, size of indeterminate nodules is poorly represented by diameter.Trial registration number Pre-results, ISRCTN63545820. ER -