PT  - JOURNAL ARTICLE
AU  - Lunt, Alan
AU  - Mortimer, Lucy
AU  - Rees, David
AU  - Height, Sue
AU  - Thein, Swee Lay
AU  - Greenough, Anne
TI  - Heterogeneity of respiratory disease in children and young adults with sickle cell disease
AID  - 10.1136/thoraxjnl-2017-210206
DP  - 2018 Jun 01
TA  - Thorax
PG  - 575--577
VI  - 73
IP  - 6
4099  - http://thorax.bmj.com/content/73/6/575.short
4100  - http://thorax.bmj.com/content/73/6/575.full
SO  - Thorax2018 Jun 01; 73
AB  - To detect and characterise different phenotypes of respiratory disease in children and young adults with sickle cell disease (SCD), 11 lung function and haematological biomarkers were analysed using k-means cluster analysis in a cohort of 114 subjects with SCD aged between 5 and 27 years. Three clusters were detected: cluster 1 had elevated pulmonary capillary blood volume, mixed obstructive/restrictive lung disease, hypoxia and moderately severe anaemia; cluster 2 were older patients with restrictive lung disease; and cluster 3 were younger patients with obstructive lung disease, elevated serum lactate dehydrogenase and bronchodilator reversibility. These results may inform more personalised management strategies to improve outcomes.