PT  - JOURNAL ARTICLE
AU  - Trethewey, Ruth
AU  - Esliger, Dale
AU  - Petherick, Emily
AU  - Evans, Rachael
AU  - Greening, Neil
AU  - James, Benjamin
AU  - Kingsnorth, Andrew
AU  - Morgan, Mike
AU  - Orme, Mark
AU  - Sherar, Lauren
AU  - Singh, Sally
AU  - Toms, Nicole
AU  - Steiner, Michael
TI  - Influence of muscle mass in the assessment of lower limb strength in COPD: validation of the prediction equation
AID  - 10.1136/thoraxjnl-2016-209870
DP  - 2018 Jun 01
TA  - Thorax
PG  - 587--589
VI  - 73
IP  - 6
4099  - http://thorax.bmj.com/content/73/6/587.short
4100  - http://thorax.bmj.com/content/73/6/587.full
SO  - Thorax2018 Jun 01; 73
AB  - Absence of established reference values limits application of quadriceps maximal voluntary contraction (QMVC) measurement. The impact of muscle mass inclusion in predictions is unclear. Prediction equations encompassing gender, age and size with (FFM+) and without (FFM−), derived in healthy adults (n=175), are presented and compared in two COPD cohorts recruited from primary care (COPD-PC, n=112) and a complex care COPD clinic (COPD-CC, n=189). Explained variance was comparable between the prediction models (R2: FFM+: 0.59, FFM−: 0.60) as were per cent predictions in COPD-PC (88.8%, 88.3%). However, fat-free mass inclusion reduced the prevalence of weakness in COPD, particularly in COPD-CC where 11.9% fewer were deemed weak.