RT Journal Article
SR Electronic
T1 Changes in dynamic lung mechanics after lung volume reduction coil treatment of severe emphysema
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 584
OP 586
DO 10.1136/thoraxjnl-2017-210118
VO 73
IS 6
A1 Makris, Demosthenes
A1 Leroy, Sylvie
A1 Pradelli, Johana
A1 Benzaquen, Jonathan
A1 Guenard, Hervé
A1 Perotin, Jeanne-Marie
A1 Zakynthinos, Spyros
A1 Zakynthinos, Epaminondas
A1 Deslee, Gaëtan
A1 Marquette, Charles Hugo
YR 2018
UL http://thorax.bmj.com/content/73/6/584.abstract
AB We assessed the relationships between changes in lung compliance, lung volumes and dynamic hyperinflation in patients with emphysema who underwent bronchoscopic treatment with nitinol coils (coil treatment) (n=11) or received usual care (UC) (n=11). Compared with UC, coil treatment resulted in decreased dynamic lung compliance (CLdyn) (p=0.03) and increased endurance time (p=0.010). The change in CLdyn was associated with significant improvement in FEV1 and FVC, with reduction in residual volume and intrinsic positive end-expiratory pressure, and with increased inspiratory capacity at rest/and at exercise. The increase in end-expiratory lung volume (EELV) during exercise (EELVdyn-ch=EELVisotime EELVrest) demonstrated significant attenuation after coil treatment (p=0.02).