PT  - JOURNAL ARTICLE
AU  - Makris, Demosthenes
AU  - Leroy, Sylvie
AU  - Pradelli, Johana
AU  - Benzaquen, Jonathan
AU  - Guenard, Hervé
AU  - Perotin, Jeanne-Marie
AU  - Zakynthinos, Spyros
AU  - Zakynthinos, Epaminondas
AU  - Deslee, Gaëtan
AU  - Marquette, Charles Hugo
TI  - Changes in dynamic lung mechanics after lung volume reduction coil treatment of severe emphysema
AID  - 10.1136/thoraxjnl-2017-210118
DP  - 2018 Jun 01
TA  - Thorax
PG  - 584--586
VI  - 73
IP  - 6
4099  - http://thorax.bmj.com/content/73/6/584.short
4100  - http://thorax.bmj.com/content/73/6/584.full
SO  - Thorax2018 Jun 01; 73
AB  - We assessed the relationships between changes in lung compliance, lung volumes and dynamic hyperinflation in patients with emphysema who underwent bronchoscopic treatment with nitinol coils (coil treatment) (n=11) or received usual care (UC) (n=11). Compared with UC, coil treatment resulted in decreased dynamic lung compliance (CLdyn) (p=0.03) and increased endurance time (p=0.010). The change in CLdyn was associated with significant improvement in FEV1 and FVC, with reduction in residual volume and intrinsic positive end-expiratory pressure, and with increased inspiratory capacity at rest/and at exercise. The increase in end-expiratory lung volume (EELV) during exercise (EELVdyn-ch=EELVisotime EELVrest) demonstrated significant attenuation after coil treatment (p=0.02).