TY - JOUR T1 - Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study JF - Thorax JO - Thorax SP - 486 LP - 488 DO - 10.1136/thoraxjnl-2017-210842 VL - 73 IS - 5 AU - Elizabeth C Oelsner AU - Benjamin M Smith AU - Eric A Hoffman AU - Aaron R Folsom AU - Steven M Kawut AU - Joel D Kaufman AU - Ani Manichaikul AU - David J Lederer AU - Joseph E Schwartz AU - Karol E Watson AU - Paul L Enright AU - John H M Austin AU - Joao A C Lima AU - Steven J Shea AU - Robert G Barr Y1 - 2018/05/01 UR - http://thorax.bmj.com/content/73/5/486.abstract N2 - Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. We used data from 2045 adult participants without initial prebronchodilator airflow limitation, classified by FEV1/FVC<0.70, in the Multi-Ethnic Study of Atherosclerosis. Emphysema-like lung on baseline cardiac CT, defined as per cent low attenuation areas<—950HU>upper limit of normal, was associated with increased odds of incident airflow limitation at 5-year follow-up on both prebronchodilator (adjusted OR 2.62, 95% CI 1.47 to 4.67) and postbronchodilator (adjusted OR 4.38, 95% CI 1.63 to 11.74) spirometry, independent of smoking history. These results support investigation into whether emphysema-like lung could be informative for COPD risk stratification. ER -