RT Journal Article
SR Electronic
T1 Acute graft-versus-host disease following lung transplantation in a patient with a novel <em>TERT</em> mutation
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 489
OP 492
DO 10.1136/thoraxjnl-2017-211121
VO 73
IS 5
A1 Brestoff, Jonathan R
A1 Vessoni, Alexandre T
A1 Brenner, Kirsten A
A1 Uy, Geoffrey L
A1 DiPersio, John F
A1 Blinder, Morey
A1 Witt, Chad A
A1 Byers, Derek E
A1 Hachem, Ramsey R
A1 Truclock, Elbert P
A1 Early, Dayna S
A1 Anadkat, Milan J
A1 Musiek, Amy
A1 Javidan-Nejad, Cylen
A1 Balfe, Dennis M
A1 Rosman, Ilana S
A1 Liu, Chang
A1 Zhang, Lingxin
A1 Despotis, George J
A1 Ruzinova, Marianna B
A1 Sehn, Jennifer K
A1 Amarillo, Ina
A1 Heusel, Jonathan W
A1 Swat, Wojcieh
A1 Kim, Brian S
A1 Wartman, Lukas D
A1 Yusen, Roger D
A1 Batista, Luis F Z
YR 2018
UL http://thorax.bmj.com/content/73/5/489.abstract
AB Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase reverse transcriptase (TERT) and short telomeres. Interstitial lung diseases have become the leading indication for lung transplantation in the USA, and recent data indicate that pathogenic mutations in telomerase may cause unfavourable outcomes following lung transplantation. Although a rare occurrence, solid organ transplant recipients who develop acute graft-versus-host disease (GVHD) have very poor survival. This case report describes the detection of a novel mutation in TERT in a patient who had lung transplantation for familial pulmonary fibrosis and died from complications of acute GVHD.