RT Journal Article SR Electronic T1 Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation JF Thorax JO Thorax FD BMJ Publishing Group Ltd and British Thoracic Society SP 489 OP 492 DO 10.1136/thoraxjnl-2017-211121 VO 73 IS 5 A1 Brestoff, Jonathan R A1 Vessoni, Alexandre T A1 Brenner, Kirsten A A1 Uy, Geoffrey L A1 DiPersio, John F A1 Blinder, Morey A1 Witt, Chad A A1 Byers, Derek E A1 Hachem, Ramsey R A1 Truclock, Elbert P A1 Early, Dayna S A1 Anadkat, Milan J A1 Musiek, Amy A1 Javidan-Nejad, Cylen A1 Balfe, Dennis M A1 Rosman, Ilana S A1 Liu, Chang A1 Zhang, Lingxin A1 Despotis, George J A1 Ruzinova, Marianna B A1 Sehn, Jennifer K A1 Amarillo, Ina A1 Heusel, Jonathan W A1 Swat, Wojcieh A1 Kim, Brian S A1 Wartman, Lukas D A1 Yusen, Roger D A1 Batista, Luis F Z YR 2018 UL http://thorax.bmj.com/content/73/5/489.abstract AB Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase reverse transcriptase (TERT) and short telomeres. Interstitial lung diseases have become the leading indication for lung transplantation in the USA, and recent data indicate that pathogenic mutations in telomerase may cause unfavourable outcomes following lung transplantation. Although a rare occurrence, solid organ transplant recipients who develop acute graft-versus-host disease (GVHD) have very poor survival. This case report describes the detection of a novel mutation in TERT in a patient who had lung transplantation for familial pulmonary fibrosis and died from complications of acute GVHD.