RT Journal Article
SR Electronic
T1 Acute graft-versus-host disease following lung transplantation in a patient with a novel <em>TERT</em> mutation
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 489
OP 492
DO 10.1136/thoraxjnl-2017-211121
VO 73
IS 5
A1 Jonathan R Brestoff
A1 Alexandre T Vessoni
A1 Kirsten A Brenner
A1 Geoffrey L Uy
A1 John F DiPersio
A1 Morey Blinder
A1 Chad A Witt
A1 Derek E Byers
A1 Ramsey R Hachem
A1 Elbert P Truclock
A1 Dayna S Early
A1 Milan J Anadkat
A1 Amy Musiek
A1 Cylen Javidan-Nejad
A1 Dennis M Balfe
A1 Ilana S Rosman
A1 Chang Liu
A1 Lingxin Zhang
A1 George J Despotis
A1 Marianna B Ruzinova
A1 Jennifer K Sehn
A1 Ina Amarillo
A1 Jonathan W Heusel
A1 Wojcieh Swat
A1 Brian S Kim
A1 Lukas D Wartman
A1 Roger D Yusen
A1 Luis F Z Batista
YR 2018
UL http://thorax.bmj.com/content/73/5/489.abstract
AB Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase reverse transcriptase (TERT) and short telomeres. Interstitial lung diseases have become the leading indication for lung transplantation in the USA, and recent data indicate that pathogenic mutations in telomerase may cause unfavourable outcomes following lung transplantation. Although a rare occurrence, solid organ transplant recipients who develop acute graft-versus-host disease (GVHD) have very poor survival. This case report describes the detection of a novel mutation in TERT in a patient who had lung transplantation for familial pulmonary fibrosis and died from complications of acute GVHD.