PT  - JOURNAL ARTICLE
AU  - Jonathan R Brestoff
AU  - Alexandre T Vessoni
AU  - Kirsten A Brenner
AU  - Geoffrey L Uy
AU  - John F DiPersio
AU  - Morey Blinder
AU  - Chad A Witt
AU  - Derek E Byers
AU  - Ramsey R Hachem
AU  - Elbert P Truclock
AU  - Dayna S Early
AU  - Milan J Anadkat
AU  - Amy Musiek
AU  - Cylen Javidan-Nejad
AU  - Dennis M Balfe
AU  - Ilana S Rosman
AU  - Chang Liu
AU  - Lingxin Zhang
AU  - George J Despotis
AU  - Marianna B Ruzinova
AU  - Jennifer K Sehn
AU  - Ina Amarillo
AU  - Jonathan W Heusel
AU  - Wojcieh Swat
AU  - Brian S Kim
AU  - Lukas D Wartman
AU  - Roger D Yusen
AU  - Luis F Z Batista
TI  - Acute graft-versus-host disease following lung transplantation in a patient with a novel <em>TERT</em> mutation
AID  - 10.1136/thoraxjnl-2017-211121
DP  - 2018 May 01
TA  - Thorax
PG  - 489--492
VI  - 73
IP  - 5
4099  - http://thorax.bmj.com/content/73/5/489.short
4100  - http://thorax.bmj.com/content/73/5/489.full
SO  - Thorax2018 May 01; 73
AB  - Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase reverse transcriptase (TERT) and short telomeres. Interstitial lung diseases have become the leading indication for lung transplantation in the USA, and recent data indicate that pathogenic mutations in telomerase may cause unfavourable outcomes following lung transplantation. Although a rare occurrence, solid organ transplant recipients who develop acute graft-versus-host disease (GVHD) have very poor survival. This case report describes the detection of a novel mutation in TERT in a patient who had lung transplantation for familial pulmonary fibrosis and died from complications of acute GVHD.