TY - JOUR T1 - Acute graft-versus-host disease following lung transplantation in a patient with a novel <em>TERT</em> mutation JF - Thorax JO - Thorax SP - 489 LP - 492 DO - 10.1136/thoraxjnl-2017-211121 VL - 73 IS - 5 AU - Jonathan R Brestoff AU - Alexandre T Vessoni AU - Kirsten A Brenner AU - Geoffrey L Uy AU - John F DiPersio AU - Morey Blinder AU - Chad A Witt AU - Derek E Byers AU - Ramsey R Hachem AU - Elbert P Truclock AU - Dayna S Early AU - Milan J Anadkat AU - Amy Musiek AU - Cylen Javidan-Nejad AU - Dennis M Balfe AU - Ilana S Rosman AU - Chang Liu AU - Lingxin Zhang AU - George J Despotis AU - Marianna B Ruzinova AU - Jennifer K Sehn AU - Ina Amarillo AU - Jonathan W Heusel AU - Wojcieh Swat AU - Brian S Kim AU - Lukas D Wartman AU - Roger D Yusen AU - Luis F Z Batista Y1 - 2018/05/01 UR - http://thorax.bmj.com/content/73/5/489.abstract N2 - Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase reverse transcriptase (TERT) and short telomeres. Interstitial lung diseases have become the leading indication for lung transplantation in the USA, and recent data indicate that pathogenic mutations in telomerase may cause unfavourable outcomes following lung transplantation. Although a rare occurrence, solid organ transplant recipients who develop acute graft-versus-host disease (GVHD) have very poor survival. This case report describes the detection of a novel mutation in TERT in a patient who had lung transplantation for familial pulmonary fibrosis and died from complications of acute GVHD. ER -