PT  - JOURNAL ARTICLE
AU  - Ki-Ho Hong
AU  - Jae-Phil Choi
AU  - Seon-Hui Hong
AU  - Jeewon Lee
AU  - Ji-Soo Kwon
AU  - Sun-Mi Kim
AU  - Se Yoon Park
AU  - Ji-Young Rhee
AU  - Baek-Nam Kim
AU  - Hee Jung Choi
AU  - Eui-Cheol Shin
AU  - Hyunjoo Pai
AU  - Su-Hyung Park
AU  - Sung-Han Kim
TI  - Predictors of mortality in Middle East respiratory syndrome (MERS)
AID  - 10.1136/thoraxjnl-2016-209313
DP  - 2018 Mar 01
TA  - Thorax
PG  - 286--289
VI  - 73
IP  - 3
4099  - http://thorax.bmj.com/content/73/3/286.short
4100  - http://thorax.bmj.com/content/73/3/286.full
SO  - Thorax2018 Mar 01; 73
AB  - We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5–10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11–16, p=0.07) during the course of disease, were associated with mortality.