PT  - JOURNAL ARTICLE
AU  - Verbanck, Sylvia
AU  - King, Gregory G
AU  - Zhou, Wenxiao
AU  - Miller, Anne
AU  - Thamrin, Cindy
AU  - Schuermans, Daniel
AU  - Ilsen, Bart
AU  - Ernst, Caroline W
AU  - de Mey, Johan
AU  - Vincken, Walter
AU  - Vanderhelst, Eef
TI  - The quantitative link of lung clearance index to bronchial segments affected by bronchiectasis
AID  - 10.1136/thoraxjnl-2017-210496
DP  - 2018 Jan 01
TA  - Thorax
PG  - 82--84
VI  - 73
IP  - 1
4099  - http://thorax.bmj.com/content/73/1/82.short
4100  - http://thorax.bmj.com/content/73/1/82.full
SO  - Thorax2018 Jan 01; 73
AB  - In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease.