PT  - JOURNAL ARTICLE
AU  - Gabriele Spina
AU  - Martijn A Spruit
AU  - Jennifer Alison
AU  - Roberto P Benzo
AU  - Peter M A Calverley
AU  - Christian F Clarenbach
AU  - Richard W Costello
AU  - David Donaire-Gonzalez
AU  - Selina Dürr
AU  - Judith Garcia-Aymerich
AU  - Arnoldus J R van Gestel
AU  - Marco Gramm
AU  - Nidia A Hernandes
AU  - Kylie Hill
AU  - Nicholas S Hopkinson
AU  - Diana Jarreta
AU  - Malcolm Kohler
AU  - Anne M Kirsten
AU  - Jörg D Leuppi
AU  - Helgo Magnussen
AU  - François Maltais
AU  - William D-C Man
AU  - Zoe J McKeough
AU  - Rafael Mesquita
AU  - David Miedinger
AU  - Fabio Pitta
AU  - Sally J Singh
AU  - Frank W J M Smeenk
AU  - Ruth Tal-Singer
AU  - Barbara Vagaggini
AU  - Benjamin Waschki
AU  - Henrik Watz
AU  - Emiel F M Wouters
AU  - Stefanie Zogg
AU  - Albertus C den Brinker
TI  - Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity
AID  - 10.1136/thoraxjnl-2016-208900
DP  - 2017 Aug 01
TA  - Thorax
PG  - 694--701
VI  - 72
IP  - 8
4099  - http://thorax.bmj.com/content/72/8/694.short
4100  - http://thorax.bmj.com/content/72/8/694.full
SO  - Thorax2017 Aug 01; 72
AB  - Background Sleep disturbances are common in patients with chronic obstructive pulmonary disease (COPD) with a considerable negative impact on their quality of life. However, factors associated with measures of sleep in daily life have not been investigated before nor has the association between sleep and the ability to engage in physical activity on a day-to-day basis been studied.Aims To provide insight into the relationship between actigraphic sleep measures and disease severity, exertional dyspnoea, gender and parts of the week; and to investigate the association between sleep measures and next day physical activity.Methods Data were analysed from 932 patients with COPD (66% male, 66.4±8.3 years, FEV1% predicted=50.8±20.5). Participants had sleep and physical activity continuously monitored using a multisensor activity monitor for a median of 6 days. Linear mixed effects models were applied to investigate the factors associated with sleep impairment and the association between nocturnal sleep and patients' subsequent daytime physical activity.Results Actigraphic estimates of sleep impairment were greater in patients with worse airflow limitation and worse exertional dyspnoea. Patients with better sleep measures (ie, non-fragmented sleep, sleeping bouts ≥225 min, sleep efficiency ≥91% and time spent awake after sleep onset <57 min) spent significantly more time in light (p<0.01) and moderate-to-vigorous physical activity (p<0.01).Conclusions There is a relationship between measures of sleep in patients with COPD and the amount of activity they undertake during the waking day. Identifying groups with specific sleep characteristics may be useful information when designing physical activity-enhancing interventions.