PT  - JOURNAL ARTICLE
AU  - Marshall, Helen
AU  - Horsley, Alex
AU  - Taylor, Chris J
AU  - Smith, Laurie
AU  - Hughes, David
AU  - Horn, Felix C
AU  - Swift, Andrew J
AU  - Parra-Robles, Juan
AU  - Hughes, Paul J
AU  - Norquay, Graham
AU  - Stewart, Neil J
AU  - Collier, Guilhem J
AU  - Teare, Dawn
AU  - Cunningham, Steve
AU  - Aldag, Ina
AU  - Wild, Jim M
TI  - Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI
AID  - 10.1136/thoraxjnl-2016-208948
DP  - 2017 Aug 01
TA  - Thorax
PG  - 760--762
VI  - 72
IP  - 8
4099  - http://thorax.bmj.com/content/72/8/760.short
4100  - http://thorax.bmj.com/content/72/8/760.full
SO  - Thorax2017 Aug 01; 72
AB  - Hyperpolarised 3He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6–16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>−1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure–function relationships.