RT Journal Article
SR Electronic
T1 Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: a randomised controlled trial (the REVIVE trial)
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 594
OP 595
DO 10.1136/thoraxjnl-2016-208723
VO 72
IS 7
A1 Kathryn McDowell
A1 Brenda O'Neill
A1 Bronagh Blackwood
A1 Chris Clarke
A1 Evie Gardner
A1 Paul Johnston
A1 Michaeline Kelly
A1 John McCaffrey
A1 Brian Mullan
A1 Sally Murphy
A1 T John Trinder
A1 Gavin Lavery
A1 Daniel F McAuley
A1 Judy M Bradley
YR 2017
UL http://thorax.bmj.com/content/72/7/594.1.abstract
AB Objective To investigate the effectiveness of a 6-week exercise programme in patients discharged home following critical illness compared with standard care.Design Multicentre prospective phase II randomised controlled trial, with blinded outcome assessment after hospital discharge, following the 6-week intervention and at 6 months.Participants 60 patients (30 per group) aged ≥18 years, mechanically ventilated >96 hours, and not in other rehabilitation, that is, cardiac or pulmonary rehabilitation programmes. Participants in the intervention group completed an individually tailored (personalised) exercise programme.Outcome measures Primary outcome measure was SF-36 physical functioning following the intervention. Secondary outcomes included a range of performance-based and patient-reported measures.Results Improvements in the primary outcome did not differ significantly between groups (mean difference (95% CI) 3.0 (−2.2 to 8.2), p=0.26). The intervention group showed significant improvement compared with the control group (mean difference (95% CI)) in SF-36 role physical (6.6 (0.73 to 12.5), p=0.03); incremental shuttle walk test (83.1 m (8.3 to 157.9), p=0.03); functional limitations profile (−4.8 (−8.7 to −0.9), p=0.02); self-efficacy to exercise (2.2 (0.8 to 3.7), p=0.01) and readiness to exercise (1.3 (0.8 to 1.9), p<0.001). These improvements were not sustained at 6 months except readiness to exercise. Improvements in all other secondary outcome measures were not significant.Conclusions There was no statistically significant difference in the primary outcome measure of self-reported physical function following this 6-week exercise programme. Secondary outcome results will help inform future studies.Trial registration number NCT01463579. (results), https://clinicaltrials.gov/