RT Journal Article SR Electronic T1 Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa JF Thorax JO Thorax FD BMJ Publishing Group Ltd and British Thoracic Society SP 666 OP 667 DO 10.1136/thoraxjnl-2016-209265 VO 72 IS 7 A1 Elaine M Waters A1 Daniel R Neill A1 Basak Kaman A1 Jaspreet S Sahota A1 Martha R J Clokie A1 Craig Winstanley A1 Aras Kadioglu YR 2017 UL http://thorax.bmj.com/content/72/7/666.abstract AB With an increase in cases of multidrug-resistant Pseudomonas aeruginosa, alternative and adjunct treatments are needed, leading to renewed interest in bacteriophage therapy. There have been few clinically relevant studies of phage therapy against chronic lung infections. Using a novel murine model that uses a natural respiratory inhalation route of infection, we show that phage therapy is an effective treatment against chronic P. aeruginosa lung infections. We also show efficacy against P. aeruginosa in a biofilm-associated cystic fibrosis lung-like environment. These studies demonstrate the potential for phage therapy in the treatment of established and recalcitrant chronic respiratory tract infections.