TY - JOUR T1 - Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD JF - Thorax JO - Thorax SP - 373 LP - 375 DO - 10.1136/thoraxjnl-2016-209673 VL - 72 IS - 4 AU - Lara Pisani AU - Luca Fasano AU - Nadia Corcione AU - Vittoria Comellini AU - Muriel Assunta Musti AU - Maria Brandao AU - Damiano Bottone AU - Edoardo Calderini AU - Paolo Navalesi AU - Stefano Nava Y1 - 2017/04/01 UR - http://thorax.bmj.com/content/72/4/373.abstract N2 - We studied the effects of high flow oxygen therapy (HFOT) versus non-invasive ventilation (NIV) on inspiratory effort, as assessed by measuring transdiaphragmatic pressure, breathing pattern and gas exchange. Fourteen patients with hypercapnic COPD underwent five 30-min trials: HFOT at two flow rates, both with open and closed mouth, and NIV, applied in random order. After each trial standard oxygen therapy was reinstituted for 10 min. Compared with baseline, HFOT and NIV significantly improved breathing pattern, although to different extents, and reduced inspiratory effort; however, arterial carbon dioxide oxygen tension decreased but not significantly. These results indicate a possible role for HFOT in the long-term management of patients with stable hypercapnic COPD.Trial registration number NCT02363920. ER -