RT Journal Article SR Electronic T1 Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD JF Thorax JO Thorax FD BMJ Publishing Group Ltd and British Thoracic Society SP 373 OP 375 DO 10.1136/thoraxjnl-2016-209673 VO 72 IS 4 A1 Lara Pisani A1 Luca Fasano A1 Nadia Corcione A1 Vittoria Comellini A1 Muriel Assunta Musti A1 Maria Brandao A1 Damiano Bottone A1 Edoardo Calderini A1 Paolo Navalesi A1 Stefano Nava YR 2017 UL http://thorax.bmj.com/content/72/4/373.abstract AB We studied the effects of high flow oxygen therapy (HFOT) versus non-invasive ventilation (NIV) on inspiratory effort, as assessed by measuring transdiaphragmatic pressure, breathing pattern and gas exchange. Fourteen patients with hypercapnic COPD underwent five 30-min trials: HFOT at two flow rates, both with open and closed mouth, and NIV, applied in random order. After each trial standard oxygen therapy was reinstituted for 10 min. Compared with baseline, HFOT and NIV significantly improved breathing pattern, although to different extents, and reduced inspiratory effort; however, arterial carbon dioxide oxygen tension decreased but not significantly. These results indicate a possible role for HFOT in the long-term management of patients with stable hypercapnic COPD.Trial registration number NCT02363920.