TY - JOUR T1 - Phage therapy is highly effective against chronic lung infections with <em>Pseudomonas aeruginosa</em> JF - Thorax JO - Thorax DO - 10.1136/thoraxjnl-2016-209265 SP - thoraxjnl-2016-209265 AU - Elaine M Waters AU - Daniel R Neill AU - Basak Kaman AU - Jaspreet S Sahota AU - Martha R J Clokie AU - Craig Winstanley AU - Aras Kadioglu Y1 - 2017/03/06 UR - http://thorax.bmj.com/content/early/2017/03/06/thoraxjnl-2016-209265.abstract N2 - With an increase in cases of multidrug-resistant Pseudomonas aeruginosa, alternative and adjunct treatments are needed, leading to renewed interest in bacteriophage therapy. There have been few clinically relevant studies of phage therapy against chronic lung infections. Using a novel murine model that uses a natural respiratory inhalation route of infection, we show that phage therapy is an effective treatment against chronic P. aeruginosa lung infections. We also show efficacy against P. aeruginosa in a biofilm-associated cystic fibrosis lung-like environment. These studies demonstrate the potential for phage therapy in the treatment of established and recalcitrant chronic respiratory tract infections. ER -