PT - JOURNAL ARTICLE AU - Young Soon Yoon AU - Jae-Woo Jung AU - Eun Ju Jeon AU - Haesook Seo AU - Yon Ju Ryu AU - Jae-Joon Yim AU - Yee Hyung Kim AU - Byoung-Hoon Lee AU - Yong Bum Park AU - Byoung Jun Lee AU - Hyun Kang AU - Jae Chol Choi TI - The effect of diabetes control status on treatment response in pulmonary tuberculosis: a prospective study AID - 10.1136/thoraxjnl-2015-207686 DP - 2017 Mar 01 TA - Thorax PG - 263--270 VI - 72 IP - 3 4099 - http://thorax.bmj.com/content/72/3/263.short 4100 - http://thorax.bmj.com/content/72/3/263.full SO - Thorax2017 Mar 01; 72 AB - Background Uncontrolled diabetes, unlike controlled diabetes, is associated with an impaired immune response. However, little is known about the impact of the status of diabetes control on clinical features and treatment outcomes in patients with pulmonary TB (PTB). We conducted this study to evaluate whether the status of diabetes control influences clinical manifestations and treatment responses in PTB.Methods A multicentre prospective study was performed between September 2012 and September 2014. The patients were categorised into three groups according to the glycated haemoglobin (HbA1C) level: PTB without diabetes mellitus (non-DM), PTB with controlled diabetes (controlled-DM) and PTB with uncontrolled diabetes (uncontrolled-DM). The primary outcome was the sputum culture conversion rate after 2 months of intensive treatment.Results Among 661 patients with PTB, 157 (23.8%) had diabetes and 108 (68.8%) had uncontrolled diabetes (HbA1C≥7.0%). The uncontrolled-DM group exhibited more symptoms, positive sputum smears (p<0.001) and presence of cavities (p<0.001) than the non-DM group. Regarding treatment responses, patients with uncontrolled-DM were more likely to have a positive culture after 2 months (p=0.009) and either treatment failure (p=0.015) or death (p=0.027) compared with the non-DM group. In contrast, those with controlled-DM showed similar treatment responses to the non-DM group. In multivariable analysis, uncontrolled diabetes was an independent risk factor for a positive sputum culture after 2 months of treatment (adjusted OR, 2.11; p=0.042) and either treatment failure or death (adjusted OR, 4.11; p=0.022).Conclusions Uncontrolled diabetes is an independent risk factor for poor treatment response in PTB.