TY - JOUR T1 - Interaction of vitamin E isoforms on asthma and allergic airway disease JF - Thorax JO - Thorax SP - 954 LP - 956 DO - 10.1136/thoraxjnl-2016-208494 VL - 71 IS - 10 AU - Joan Cook-Mills AU - Tebeb Gebretsadik AU - Hiam Abdala-Valencia AU - Jeremy Green AU - Emma K Larkin AU - William D Dupont AU - Xiao Ou Shu AU - Myron Gross AU - Chunxue Bai AU - Yu-Tang Gao AU - Terryl J Hartman AU - Christian Rosas-Salazar AU - Tina Hartert Y1 - 2016/10/01 UR - http://thorax.bmj.com/content/71/10/954.abstract N2 - Prospective epidemiological studies, observational cross-sectional studies and some randomised prevention trials have demonstrated inconsistent findings of the impact of vitamin E on asthma risk. The goals of this study were to explore whether this differing association of vitamin E on asthma risk is due to an interaction of vitamin E isoforms. To address this question, in a population-based asthma incidence study we assessed the interaction between the plasma concentrations of vitamin E isoforms α-tocopherol and γ-tocopherol on asthma risk. Second, to understand the mechanisms of any interaction of these isoforms, we conducted experimental supplementation of α-tocopherol and γ-tocopherol isoforms in mice on the outcome of allergic airway inflammation. We found that in the highest γ-tocopherol tertile, low levels of α-tocopherol were associated with increased asthma risk, while highest tertile α-tocopherol levels trended to be protective. Similarly, in a mouse model of asthma, diet supplementation with α-tocopherol decreased lung inflammation in response to house dust mite (HDM) challenge. In contrast, diet supplementation with γ-tocopherol increased lung inflammation in response to HDM. These human and animal studies provide evidence for the competing effects of the vitamin E isoforms, in physiological concentrations, on asthma and allergic airway disease. ER -