TY - JOUR T1 - US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis JF - Thorax JO - Thorax SP - i1 LP - i22 DO - 10.1136/thoraxjnl-2015-207360 VL - 71 IS - Suppl 1 AU - R Andres Floto AU - Kenneth N Olivier AU - Lisa Saiman AU - Charles L Daley AU - Jean-Louis Herrmann AU - Jerry A Nick AU - Peadar G Noone AU - Diana Bilton AU - Paul Corris AU - Ronald L Gibson AU - Sarah E Hempstead AU - Karsten Koetz AU - Kathryn A Sabadosa AU - Isabelle Sermet-Gaudelus AU - Alan R Smyth AU - Jakko van Ingen AU - Richard J Wallace AU - Kevin L Winthrop AU - Bruce C Marshall AU - Charles S Haworth Y1 - 2016/01/01 UR - http://thorax.bmj.com/content/71/Suppl_1/i1.abstract N2 - Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause chronic pulmonary infection, particularly in individuals with pre-existing inflammatory lung disease such as cystic fibrosis (CF). Pulmonary disease caused by NTM has emerged as a major threat to the health of individuals with CF but remains difficult to diagnose and problematic to treat. In response to this challenge, the US Cystic Fibrosis Foundation (CFF) and the European Cystic Fibrosis Society (ECFS) convened an expert panel of specialists to develop consensus recommendations for the screening, investigation, diagnosis and management of NTM pulmonary disease in individuals with CF. Nineteen experts were invited to participate in the recommendation development process. Population, Intervention, Comparison, Outcome (PICO) methodology and systematic literature reviews were employed to inform draft recommendations. An anonymous voting process was used by the committee to reach consensus. All committee members were asked to rate each statement on a scale of: 0, completely disagree, to 9, completely agree; with 80% or more of scores between 7 and 9 being considered ‘good’ agreement. Additionally, the committee solicited feedback from the CF communities in the USA and Europe and considered the feedback in the development of the final recommendation statements. Three rounds of voting were conducted to achieve 80% consensus for each recommendation statement. Through this process, we have generated a series of pragmatic, evidence-based recommendations for the screening, investigation, diagnosis and treatment of NTM infection in individuals with CF as an initial step in optimising management for this challenging condition. ER -