RT Journal Article
SR Electronic
T1 ‘LungGENS’: a web-based tool for mapping single-cell gene expression in the developing lung
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 1092
OP 1094
DO 10.1136/thoraxjnl-2015-207035
VO 70
IS 11
A1 Du, Yina
A1 Guo, Minzhe
A1 Whitsett, Jeffrey A
A1 Xu, Yan
YR 2015
UL http://thorax.bmj.com/content/70/11/1092.abstract
AB We developed LungGENS (Lung Gene Expression iN Single-cell), a web-based bioinformatics resource for querying single-cell gene expression databases by entering a gene symbol or a list of genes or selecting a cell type of their interest. Gene query provides quantitative RNA expression of the gene of interest in each lung cell type. Cell type query returns associated selective gene signatures and genes encoding cell surface markers and transcription factors in interactive heatmap and tables. LungGENS will be broadly applicable in respiratory research, providing a cell-specific RNA expression resource at single-cell resolution. LungGENS is freely available for non-commercial use at https://research.cchmc.org/pbge/lunggens/default.html.