RT Journal Article
SR Electronic
T1 The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 998
OP 1000
DO 10.1136/thoraxjnl-2015-207246
VO 70
IS 10
A1 Padmaja Subbarao
A1 Sonia S Anand
A1 Allan B Becker
A1 A Dean Befus
A1 Michael Brauer
A1 Jeffrey R Brook
A1 Judah A Denburg
A1 Kent T HayGlass
A1 Michael S Kobor
A1 Tobias R Kollmann
A1 Anita L Kozyrskyj
A1 W Y Wendy Lou
A1 Piushkumar J Mandhane
A1 Gregory E Miller
A1 Theo J Moraes
A1 Peter D Pare
A1 James A Scott
A1 Tim K Takaro
A1 Stuart E Turvey
A1 Joanne M Duncan
A1 Diana L Lefebvre
A1 Malcolm R Sears
A1 the CHILD Study investigators
YR 2015
UL http://thorax.bmj.com/content/70/10/998.abstract
AB The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that early life physical and psychosocial environments, immunological, physiological, nutritional, hormonal and metabolic influences interact with genetics influencing allergic diseases, including asthma. Environmental and biological sampling, innate and adaptive immune responses, gene expression, DNA methylation, gut microbiome and nutrition studies complement repeated environmental and clinical assessments to age 5. This rich data set, linking prenatal and postnatal environments, diverse biological samples and rigorous phenotyping, will inform early developmental pathways to allergy, asthma and other chronic inflammatory diseases.