TY - JOUR T1 - The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma JF - Thorax JO - Thorax SP - 998 LP - 1000 DO - 10.1136/thoraxjnl-2015-207246 VL - 70 IS - 10 AU - Padmaja Subbarao AU - Sonia S Anand AU - Allan B Becker AU - A Dean Befus AU - Michael Brauer AU - Jeffrey R Brook AU - Judah A Denburg AU - Kent T HayGlass AU - Michael S Kobor AU - Tobias R Kollmann AU - Anita L Kozyrskyj AU - W Y Wendy Lou AU - Piushkumar J Mandhane AU - Gregory E Miller AU - Theo J Moraes AU - Peter D Pare AU - James A Scott AU - Tim K Takaro AU - Stuart E Turvey AU - Joanne M Duncan AU - Diana L Lefebvre AU - Malcolm R Sears AU - the CHILD Study investigators Y1 - 2015/10/01 UR - http://thorax.bmj.com/content/70/10/998.abstract N2 - The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that early life physical and psychosocial environments, immunological, physiological, nutritional, hormonal and metabolic influences interact with genetics influencing allergic diseases, including asthma. Environmental and biological sampling, innate and adaptive immune responses, gene expression, DNA methylation, gut microbiome and nutrition studies complement repeated environmental and clinical assessments to age 5. This rich data set, linking prenatal and postnatal environments, diverse biological samples and rigorous phenotyping, will inform early developmental pathways to allergy, asthma and other chronic inflammatory diseases. ER -