TY - JOUR T1 - Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence JF - Thorax JO - Thorax SP - 648 LP - 653 DO - 10.1136/thoraxjnl-2013-204102 VL - 69 IS - 7 AU - M A CaƱizares AU - J M Matilla AU - A Cueto AU - J Algar AU - I Muguruza AU - N Moreno-Mata AU - R Moreno-Balsalobre AU - R Guijarro AU - R Arrabal AU - E Garcia-Fontan AU - A Gonzalez-PiƱeiro AU - M Garcia-Yuste AU - EMETNE-SEPAR Members Y1 - 2014/07/01 UR - http://thorax.bmj.com/content/69/7/648.abstract N2 - Background Atypical carcinoids (AC) of the lung are rare intermediate-grade neuroendocrine neoplasms. Prognostic factors for these tumours are undefined. Methods Our cooperative group retrieved data on 127 patients operated between 1980 and 2009 because of an AC. Several clinical and pathological features were studied. Results In a univariable analysis, T-status (p=0.005), N-status (p=0.021), preoperative M-status (previously treated) (p=0.04), and distant recurrence developed during the outcome (p<0.001) presented statistically significant differences related to survival of these patients. In a multivariable analysis, only distant recurrence was demonstrated to be an independent risk factor for survival (p<0.001; HR: 13.1). During the monitoring, 25.2% of the patients presented some kind of recurrence. When we studied recurrence factors in a univariable manner, sublobar resections presented significant relationship with locoregional recurrence (p<0.001). In the case of distant recurrence, T and N status presented significant differences. Patients with preoperative M1 status presented higher frequencies of locoregional and distant recurrence (p=0.004 and p<0.001, respectively). In a multivariable analysis, sublobar resection was an independent prognostic factor to predict locoregional recurrence (p=0.002; HR: 18.1). Conclusions Complete standard surgical resection with radical lymphadenectomy is essential for AC. Sublobar resections are related to locoregional recurrence, so they should be avoided except for carefully selected patients. Nodal status is an important prognostic factor to predict survival and recurrence. Distant recurrence is related to poor outcome. ER -