PT  - JOURNAL ARTICLE
AU  - M A Cañizares
AU  - J M Matilla
AU  - A Cueto
AU  - J Algar
AU  - I Muguruza
AU  - N Moreno-Mata
AU  - R Moreno-Balsalobre
AU  - R Guijarro
AU  - R Arrabal
AU  - E Garcia-Fontan
AU  - A Gonzalez-Piñeiro
AU  - M Garcia-Yuste
AU  - EMETNE-SEPAR Members
TI  - Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence
AID  - 10.1136/thoraxjnl-2013-204102
DP  - 2014 Jul 01
TA  - Thorax
PG  - 648--653
VI  - 69
IP  - 7
4099  - http://thorax.bmj.com/content/69/7/648.short
4100  - http://thorax.bmj.com/content/69/7/648.full
SO  - Thorax2014 Jul 01; 69
AB  - Background Atypical carcinoids (AC) of the lung are rare intermediate-grade neuroendocrine neoplasms. Prognostic factors for these tumours are undefined. Methods Our cooperative group retrieved data on 127 patients operated between 1980 and 2009 because of an AC. Several clinical and pathological features were studied. Results In a univariable analysis, T-status (p=0.005), N-status (p=0.021), preoperative M-status (previously treated) (p=0.04), and distant recurrence developed during the outcome (p<0.001) presented statistically significant differences related to survival of these patients. In a multivariable analysis, only distant recurrence was demonstrated to be an independent risk factor for survival (p<0.001; HR: 13.1). During the monitoring, 25.2% of the patients presented some kind of recurrence. When we studied recurrence factors in a univariable manner, sublobar resections presented significant relationship with locoregional recurrence (p<0.001). In the case of distant recurrence, T and N status presented significant differences. Patients with preoperative M1 status presented higher frequencies of locoregional and distant recurrence (p=0.004 and p<0.001, respectively). In a multivariable analysis, sublobar resection was an independent prognostic factor to predict locoregional recurrence (p=0.002; HR: 18.1). Conclusions Complete standard surgical resection with radical lymphadenectomy is essential for AC. Sublobar resections are related to locoregional recurrence, so they should be avoided except for carefully selected patients. Nodal status is an important prognostic factor to predict survival and recurrence. Distant recurrence is related to poor outcome.