TY - JOUR T1 - Reasons for heterogeneous change in LCI in children with cystic fibrosis after antibiotic treatment JF - Thorax JO - Thorax SP - 183 LP - 183 DO - 10.1136/thoraxjnl-2013-204283 VL - 69 IS - 2 AU - Sophie Yammine AU - Anja Bigler AU - Carmen Casaulta AU - Florian Singer AU - Philipp Latzin Y1 - 2014/02/01 UR - http://thorax.bmj.com/content/69/2/183.abstract N2 - With great interest we read the paper of Horsley et al.1 In their prospective observational study they showed significant improvement in indices of ventilation capacity (spirometry) and ventilation heterogeneity (multiple-breath washout (MBW)) after a course of intravenous antibiotics in subjects with cystic fibrosis (CF). There was considerable heterogeneity of lung clearance index (LCI) response as observed previously.2 Here we aim to disentangle underlying physiological mechanisms of this heterogeneous response. We assessed changes of lung function parameters before and after 23 courses of intravenous antibiotics in 19 children with CF aged 5–18 years. Children performed arterial blood oxygen measurement, nitrogen MBW,3 , … ER -