RT Journal Article
SR Electronic
T1 Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT: final results after a 5-year screening programme
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 574
OP 579
DO 10.1136/thoraxjnl-2013-203849
VO 69
IS 6
A1 Ashraf, Haseem
A1 Saghir, Zaigham
A1 Dirksen, Asger
A1 Pedersen, Jesper Holst
A1 Thomsen, Laura Hohwü
A1 Døssing, Martin
A1 Tønnesen, Philip
YR 2014
UL http://thorax.bmj.com/content/69/6/574.abstract
AB Background We present the final results of the effect of lung cancer screening with low-dose CT on the smoking habits of participants in a 5-year screening trial. Methods The Danish Lung Cancer Screening Trial (DLCST) was a 5-year screening trial that enrolled 4104 subjects; 2052 were randomised to annual low-dose CT (CT group) and 2052 received no intervention (control group). Participants were current and ex-smokers (≥4 weeks abstinence from smoking) with a tobacco consumption of ≥20 pack years. Smoking habits were determined annually. Missing values for smoking status at the final screening round were handled using two different models. Results There were no statistically significant differences in annual smoking status between the CT group and control group. Overall the ex-smoker rates (CT + control group) significantly increased from 24% (baseline) to 37% at year 5 of screening (p<0.001). The annual point prevalence quit rate increased from 11% to 24% during the five screening rounds; the ex-smokers’ relapse rate remained stable, around 11%, across the same period. Conclusions Screening with low-dose CT had no extra effect on smoking status compared with the control group, but overall the screening programme probably promoted smoking cessation. Clinical Trial Registration: The DLCST is registered in Clinical Trials.gov Protocol Registration System (identification no. NCT00496977).