TY - JOUR T1 - Authors’ response to Metzdorf <em>et al</em> JF - Thorax JO - Thorax SP - 782 LP - 783 DO - 10.1136/thoraxjnl-2013-203380 VL - 68 IS - 8 AU - Christine R Jenkins AU - Richard Beasley Y1 - 2013/08/01 UR - http://thorax.bmj.com/content/68/8/782.2.abstract N2 - We appreciate the contribution to this discussion from Metzdorf et al 1, and the efforts made by the company to assess the safety of the Handihaler and Respimat through pooling datasets from randomised controlled trials. We would like reassurance that the pooled analysis of the three 1-year and one 6-month placebo-controlled trials with Spiriva Respimat detailed on the product information website was based on an intention to treat … ER -