RT Journal Article
SR Electronic
T1 Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 380
OP 384
DO 10.1136/thoraxjnl-2012-201902
VO 68
IS 4
A1 Susanne Krauss-Etschmann
A1 Andrew Bush
A1 Saverio Bellusci
A1 Guy G Brusselle
A1 Sven Erik K Dahlén
A1 Stefan Dehmel
A1 Oliver Eickelberg
A1 Greg Gibson
A1 Machteld N Hylkema
A1 Petra Knaus
A1 Melanie Königshoff
A1 Clare M Lloyd
A1 Paolo Macciarini
A1 Arnaud Mailleux
A1 Benjamin J Marsland
A1 Dirkje S Postma
A1 Graham Roberts
A1 Christos Samakovlis
A1 Janet Stocks
A1 Joke Vandesompele
A1 Matthias Wjst
A1 John Holloway
YR 2013
UL http://thorax.bmj.com/content/68/4/380.abstract
AB Despite intensive research efforts, the aetiology of the majority of chronic lung diseases (CLD) in both, children and adults, remains elusive. Current therapeutic options are limited, providing only symptomatic relief, rather than treating the underlying condition, or preventing its development in the first place. Thus, there is a strong and unmet clinical need for the development of both, novel effective therapies and preventative strategies for CLD. Many studies suggest that modifications of prenatal and/or early postnatal lung development will have important implications for future lung function and risk of CLD throughout life. This view represents a fundamental change of current pathophysiological concepts and treatment paradigms, and holds the potential to develop novel preventative and/or therapeutic strategies. However, for the successful development of such approaches, key questions, such as a clear understanding of underlying mechanisms of impaired lung development, the identification and validation of relevant preclinical models to facilitate translational research, and the development of concepts for correction of aberrant development, all need to be solved. Accordingly, a European Science Foundation Exploratory Workshop was held where clinical, translational and basic research scientists from different disciplines met to discuss potential mechanisms of developmental origins of CLD, and to identify major knowledge gaps in order to delineate a roadmap for future integrative research.