TY - JOUR T1 - What is top of the charts? BPIFB1/LPLUNC1 localises to the bronchiolised epithelium in the honeycomb cysts in UIP JF - Thorax JO - Thorax SP - 1167 LP - 1168 DO - 10.1136/thoraxjnl-2013-204179 VL - 68 IS - 12 AU - Colin D Bingle AU - Bianca Araujo AU - William A Wallace AU - Nik Hirani AU - Lynne Bingle Y1 - 2013/12/01 UR - http://thorax.bmj.com/content/68/12/1167.abstract N2 - Transcriptomic analyses are increasingly being used to define the molecular phenotype of complex diseases and may yet allow the identification of novel diagnostic and prognostic markers. Yang et al1 are to be congratulated for their meticulous application of this technology to the systematic study of gene signatures from patients with Idiopathic Pulmonary Fibrosis (IPF). This study, which appears to be the largest data set yet published, identifies two distinct gene signatures with high expression of ‘cilium-associated genes’ being shown to be associated with cases that exhibit microscopic honeycombing, which is commonly observed in, but not specific to, ‘Usual Interstitial Pneumonia’ (UIP), the pathological pattern of remodelling seen in IPF. This metaplastic bronchial type epithelium within the honeycomb spaces has recently been the … ER -