RT Journal Article
SR Electronic
T1 Electron tomography of respiratory cilia
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 190
OP 191
DO 10.1136/thoraxjnl-2012-202938
VO 68
IS 2
A1 Amelia Shoemark
A1 Claire Hogg
YR 2013
UL http://thorax.bmj.com/content/68/2/190.abstract
AB Cilia are organelles present on almost every cell within the body. In the respiratory tract, motile cilia line the epithelial surface and beat in a coordinated fashion to clear mucus from the airways. Mucociliary dysfunction is implicated in a number of lung diseases including cystic fibrosis, chronic obstructive pulmonary disease, bronchiectasis and primary ciliary dyskinesia. Recent microscopy advances such as electron tomography have developed our understanding of the structure and function of these important organelles. In this review we discuss electron tomography and its relevance to respiratory cilia.