RT Journal Article SR Electronic T1 Single versus combination antibiotic therapy in adults hospitalised with community acquired pneumonia JF Thorax JO Thorax FD BMJ Publishing Group Ltd and British Thoracic Society SP 493 OP 495 DO 10.1136/thoraxjnl-2012-202296 VO 68 IS 5 A1 Chamira Rodrigo A1 Tricia M Mckeever A1 Mark Woodhead A1 Wei Shen Lim A1 on behalf of the British Thoracic Society YR 2013 UL http://thorax.bmj.com/content/68/5/493.abstract AB The benefits of β-lactam/macrolide combination therapy over β-lactam therapy alone for the treatment of hospitalised community-acquired pneumonia (CAP) in relation to pneumonia severity are uncertain. We studied 5240 adults hospitalised with CAP from 72 secondary care trusts across England and Wales. The overall 30-day inpatient (IP) death rate was 24.4%. Combination therapy was prescribed in 3239 (61.8%) patients. In a multivariable model, combination therapy was significantly associated with lower 30-day IP death rate in patients with moderate-severity CAP (adjusted OR 0.54, 95% CI 0.41 to 0.72) and high-severity CAP (adjusted OR 0.76, 95% CI 0.60 to 0.96) but not low-severity CAP.