TY - JOUR T1 - Highlights from this issue JF - Thorax JO - Thorax SP - i LP - i DO - 10.1136/thoraxjnl-2012-202790 VL - 67 IS - 11 AU - Andrew Bush AU - Ian Pavord Y1 - 2012/11/01 UR - http://thorax.bmj.com/content/67/11/i.abstract N2 - Many of us are following the vitamin D papers with the same apprehension as we contemplate our erratic teenage sons—huge potential for future good, but how much damage may be done to the family home and the parental psyche in the meantime? In this issue of Thorax, we feature two contributions to the unfolding Vitamin D story. In Basic Science for the Chest Physician, Pfeffer and Hawrylowicz steer the non-immunologists through the complexities of the actions of 1,25(OH)D3, which is now known to be generated in far more organs than just the kidney, the nuclear Vitamin D receptor, and the end-results on the expression of genes concerned in the adaptive and immune responses (see page 1017). Although Vitamin D deficiency seems to have numerous adverse effects in a number of respiratory diseases, is it true that D is good but is more better? Not so, say the Southampton group, at least in pregnancy (see page 950); there was no relationship between maternal serum Vitamin D at 34 weeks … ER -