TY - JOUR T1 - Smoking, acute mountain sickness and altitude acclimatisation: a cohort study JF - Thorax JO - Thorax SP - 914 LP - 919 DO - 10.1136/thoraxjnl-2011-200623 VL - 67 IS - 10 AU - Tian-Yi Wu AU - Shou-Quan Ding AU - Jin-Liang Liu AU - Jian-Hou Jia AU - Zuo-Chun Chai AU - Rui-Chen Dai AU - Ji-Zhui Zhao AU - Qi De Tang AU - Bengt Kayser Y1 - 2012/10/01 UR - http://thorax.bmj.com/content/67/10/914.abstract N2 - Rationale The relationship between cigarette smoking and acute mountain sickness (AMS) is not clear. Objective To assess AMS risk and altitude acclimatisation in relation to smoking. Methods 200 healthy non-smokers and 182 cigarette smokers were recruited from Han lowland workers. These were men without prior altitude exposure, matched for age, health status and occupation, who were transported to an altitude of 4525 masl. Measurements AMS, smoking habits, arterial saturation (SpO2), haemoglobin (Hb), lung function and mean pulmonary artery pressure (PAPm) were assessed upon arrival and after 3 and 6 months. Main results Compared with non-smokers, smokers had a lower incidence of AMS and lower AMS scores than non-smokers upon arrival; higher Hb and PAPm associated with lower SpO2 at 3 and 6 months at altitude; and lower forced expiratory volume in 1 s and maximal voluntary ventilation at 3 and 6 months. Conclusions Smoking slightly decreases the risk of AMS but impairs long-term altitude acclimatisation and lung function during a prolonged stay at high altitude. ER -