RT Journal Article
SR Electronic
T1 Regulation of inflammatory responses by the commensal microbiota
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 93
OP 94
DO 10.1136/thoraxjnl-2011-200750
VO 67
IS 1
A1 Marsland, Benjamin J
YR 2012
UL http://thorax.bmj.com/content/67/1/93.abstract
AB It is well established that dysregulation of the interactions between the immune system and commensal bacteria is one factor that underpins the development and chronicity of a number of inflammatory diseases. Certain phyla of bacteria within the microbiota have been associated with ‘health’, but the mechanisms by which the presence of these bacteria supports a healthy environment are still being unravelled. Recent evidence indicates that one such mechanism involves the anti-inflammatory properties of fermentation products of fibre, short-chain fatty acids and their signalling through the G-protein coupled receptor GPR43. Recent findings also indicate that, even in health, bacterial communities harbour in the airways, indicating that direct exposure to bacterial products at this site may provide a further explanation for how commensal bacteria can regulate chronic airway inflammation.