PT  - JOURNAL ARTICLE
AU  - Anne-Laure Borel
AU  - Xavier Leblanc
AU  - Natalie Alméras
AU  - Angelo Tremblay
AU  - Jean Bergeron
AU  - Paul Poirier
AU  - Jean-Pierre Després
AU  - Frédéric Series
TI  - Sleep apnoea attenuates the effects of a lifestyle intervention programme in men with visceral obesity
AID  - 10.1136/thoraxjnl-2011-201001
DP  - 2012 Aug 01
TA  - Thorax
PG  - 735--741
VI  - 67
IP  - 8
4099  - http://thorax.bmj.com/content/67/8/735.short
4100  - http://thorax.bmj.com/content/67/8/735.full
SO  - Thorax2012 Aug 01; 67
AB  - Background Excess visceral adiposity and sleep apnoea are two conditions independently associated with cardiovascular diseases. The two conditions are often combined and are believed to interact in a vicious circle.Objectives To compare the response of men with visceral obesity with or without sleep apnoea syndrome to a 1-year healthy eating, physical activity/exercise intervention programme.Methods 77 men, selected on the basis of increased waist circumference (≥90 cm) and dyslipidaemia (triglycerides ≥1.69 and/or high-density lipoprotein (HDL) cholesterol <1.03 mmol/litre), participated in this study. Body composition and fat distribution were assessed by dual-emission X-ray absorptiometry or CT and sleep breathing disorders by home-based polygraphic recording. Cardiorespiratory fitness, plasma adipokines, plasma inflammatory markers, fasting lipoprotein–lipid profile and oral glucose tolerance test were assessed.Results After the 1-year lifestyle intervention, the mean oxygen desaturation index (ODI) of the whole sample decreased (−3±13 events/h, p<0.05). Men with sleep apnoea syndrome at baseline (ODI ≥10 events/h, n=28) showed smaller reductions in body mass index, waist circumference, triglycerides and smaller increases in HDL cholesterol and adiponectin than men without sleep apnoea (ODI <10 events/h, n=49), despite similar compliance to the programme. The higher the baseline ODI and the time spent under 90% saturation, the lower the reductions in fat mass and visceral adiposity, and the smaller the improvement in glucose/insulin homeostasis indices after 1 year.Conclusions Men with sleep apnoea syndrome at baseline had smaller reduction in body weight and less metabolic improvements associated with the lifestyle intervention programme than men without sleep apnoea syndrome.