TY - JOUR T1 - Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking? JF - Thorax JO - Thorax SP - 961 LP - 969 DO - 10.1136/thoraxjnl-2011-200010 VL - 66 IS - 11 AU - Bram van den Borst AU - Annemarie Koster AU - Binbing Yu AU - Harry R Gosker AU - Bernd Meibohm AU - Douglas C Bauer AU - Stephen B Kritchevsky AU - Yongmei Liu AU - Anne B Newman AU - Tamara B Harris AU - Annemie M W J Schols AU - For the Health ABC Study Y1 - 2011/11/01 UR - http://thorax.bmj.com/content/66/11/961.abstract N2 - Background and aims Cross-sectional studies suggest that obstructive lung disease (OLD) and smoking affect lean mass and mobility. A study was undertaken to investigate whether OLD and smoking accelerate the ageing-related decline in lean mass and physical functioning.Methods 260 patients with OLD (mean±SD forced expiratory volume in 1 s (FEV1) 63±18% predicted), 157 smoking controls (FEV1 95±16% predicted), 866 former-smoking controls (FEV1 100±16% predicted) and 891 never-smoking controls (FEV1 104±17% predicted) participating in the Health, Aging and Body Composition (ABC) Study were studied. At baseline the mean age was 74±3 years and participants reported no functional limitations. Baseline and 7-year longitudinal data of body composition (by dual-energy x-ray absorptiometry), muscle strength (by hand and leg dynamometry) and Short Physical Performance Battery (SPPB) were investigated.Results Compared with never-smoking controls, patients with OLD and smoking controls had a significantly lower weight, fat mass, lean mass and bone mineral content (BMC) at baseline (p<0.05). While the loss of weight, fat mass, lean mass and strength was comparable between patients with OLD and never-smoking controls, the SPPB declined 0.12 points/year faster in men with OLD (p=0.01) and BMC declined 4 g/year faster in women with OLD (p=0.02). In smoking controls only lean mass declined 0.1 kg/year faster in women (p=0.03) and BMC 8 g/year faster in men (p=0.02) compared with never-smoking controls.Conclusions Initially well-functioning older adults with mild-to-moderate OLD and smokers without OLD have a comparable compromised baseline profile of body composition and physical functioning, while 7-year longitudinal trajectories are to a large extent comparable to those observed in never-smokers without OLD. This suggests a common insult earlier in life related to smoking. ER -