TY - JOUR T1 - Longevity of alveolar macrophages allow sustained in vivo expression of the human α1-antitrypsin gene and amelioration of emphysema JF - Thorax JO - Thorax SP - 371 LP - 371 DO - 10.1136/thx.2010.136275 VL - 65 IS - 4 AU - Toni Jordan Y1 - 2010/04/01 UR - http://thorax.bmj.com/content/65/4/371.abstract N2 - This study describes the transduction of mouse pulmonary alveolar macrophages using an intratracheally instilled lentiviral vector. The transferred genes were expressed in vivo for the duration of the lifespan of the mouse. Labelling studies using bromodeoxyuridine (BrdU) revealed continued expression of the transgenes by alveolar macrophages present in the … ER -