RT Journal Article
SR Electronic
T1 School age outcome of hospitalisation with respiratory syncytial virus infection of prematurely born infants
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 490
OP 495
DO 10.1136/thx.2008.095547
VO 64
IS 6
A1 A Greenough
A1 J Alexander
A1 P Boit
A1 J Boorman
A1 S Burgess
A1 A Burke
A1 P A Chetcuti
A1 I Cliff
A1 W Lenney
A1 T Lytle
A1 C Morgan
A1 C Raiman
A1 N J Shaw
A1 K P Sylvester
A1 J Turner
YR 2009
UL http://thorax.bmj.com/content/64/6/490.abstract
AB Background: Hospitalisation due to respiratory syncytial virus (RSV) infection in the first 2 years after birth has been associated with increased healthcare utilisation and associated costs up to 5 years of age in children born prematurely at less than 32 weeks of gestation who developed bronchopulmonary dysplasia (BPD). A study was undertaken to determine whether hospitalisation due to RSV infection in the first 2 years was associated with increased morbidity and lung function abnormalities in such children at school age, and if any effects were influenced by age.Methods: Healthcare utilisation and cost of care in years 5–7 were reviewed in 147 children and changes in healthcare utilisation between 0 and 8 years were assessed also using results from two previous studies. At age 8–10 years, 77 children had their lung function assessed and bronchial hyper-responsiveness determined.Results: Children hospitalised with RSV infection (n = 25) in the first 2 years had a greater cost of care related to outpatient attendance than those with a non-respiratory or no admission (n = 72) when aged 5–7 years (p = 0.008). At 8–10 years of age, children hospitalised with RSV infection (n = 14) had lower forced expiratory volume in 0.75 s (FEV0.75) (p = 0.015), FEV0.75/forced vital capacity (p = 0.027) and flows at 50% (p = 0.034) and 75% (p = 0.006) of vital capacity than children hospitalised for non-RSV causes (n = 63). Healthcare utilisation decreased with increasing age regardless of RSV hospitalisation status.Conclusions: In prematurely born children who had BPD, hospitalisation due to RSV infection in the first 2 years is associated with reduced airway calibre at school age.