TY - JOUR T1 - Fungi and pollen exposure in the first months of life and risk of early childhood wheezing JF - Thorax JO - Thorax SP - 353 LP - 358 DO - 10.1136/thx.2007.090241 VL - 64 IS - 4 AU - K G Harley AU - J M Macher AU - M Lipsett AU - P Duramad AU - N T Holland AU - S S Prager AU - J Ferber AU - A Bradman AU - B Eskenazi AU - I B Tager Y1 - 2009/04/01 UR - http://thorax.bmj.com/content/64/4/353.abstract N2 - Background: Many studies have found that the risk of childhood asthma varies by month of birth, but few have examined ambient aeroallergens as an explanatory factor. A study was undertaken to examine whether birth during seasons of elevated ambient fungal spore or pollen concentrations is associated with risk of early wheezing or blood levels of Th1 and Th2 type cells at 24 months of age.Methods: 514 children were enrolled before birth and followed to 24 months of age. Early wheezing was determined from medical records, and Th1 and Th2 type cells were measured in peripheral blood using flow cytometry. Ambient aeroallergen concentrations were measured throughout the study period and discrete seasons of high spore and pollen concentrations were defined.Results: A seasonal pattern was observed, with birth in autumn to winter (the spore season) associated with increased odds of early wheezing (adjusted odds ratio 3.1; 95% confidence interval 1.3 to 7.4). Increasing mean daily concentrations of basidiospores and ascospores in the first 3 months of life were associated with increased odds of wheeze, as were increasing mean daily concentrations of total and specific pollen types. Levels of Th1 cells at age 24 months were positively associated with mean spore concentrations and negatively associated with mean pollen concentrations in the first 3 months of life.Conclusions: Children with higher exposure to spores and pollen in the first 3 months of life are at increased risk of early wheezing. This association is independent of other seasonal factors including ambient levels of particulate matter of aerodynamic diameter ⩽2.5 μm and lower respiratory infections. ER -