TY - JOUR T1 - Pharmacogenetic basis for severe asthma exacerbations JF - Thorax JO - Thorax SP - 429 LP - 429 VL - 63 IS - 5 AU - Shoaib Faruqi Y1 - 2008/05/01 UR - http://thorax.bmj.com/content/63/5/429.abstract N2 - Activation of CD23, a low affinity IgE receptor, results in downregulation of IgE-mediated immune responses. CD23 is encoded for by the Fc fragment of IgE low affinity II receptor (FCER2) gene. IgE levels may increase in children with asthma treated with inhaled corticosteroids, and this may be explained by a decrease in FCER2 expression by corticosteroids. Also, elevated IgE levels are … ER -