RT Journal Article
SR Electronic
T1 Pulmonary veno-occlusive disease presenting with recurrent pulmonary oedema and the use of nitric oxide to predict response to sildenafil
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 933
OP 934
DO 10.1136/thx.2007.088831
VO 63
IS 10
A1 B C Creagh-Brown
A1 A G Nicholson
A1 R Showkathali
A1 J S R Gibbs
A1 L S G E Howard
YR 2008
UL http://thorax.bmj.com/content/63/10/933.abstract
AB Pulmonary veno-occlusive disease (PVOD) is a disorder which causes progressive pulmonary hypertension, usually presenting with worsening dyspnoea and right heart failure. Pulmonary oedema induced by pulmonary vasodilator therapy to reduce pulmonary arterial pressure has been well described in PVOD, but here we describe a case of PVOD presenting with recurrent episodes of acute non-cardiogenic pulmonary oedema, in the absence of significant pulmonary hypertension. Concern over the risk of precipitating pulmonary oedema led us to use inhaled nitric oxide to predict the safety and efficacy of sildenafil.