RT Journal Article SR Electronic T1 Early growth and adult respiratory function in men and women followed from the fetal period to adulthood JF Thorax JO Thorax FD BMJ Publishing Group Ltd and British Thoracic Society SP 396 OP 402 DO 10.1136/thx.2006.066241 VO 62 IS 5 A1 Canoy, Dexter A1 Pekkanen, Juha A1 Elliott, Paul A1 Pouta, Anneli A1 Laitinen, Jaana A1 Hartikainen, Anna-Liisa A1 Zitting, Paavo A1 Patel, Swatee A1 Little, Mark P A1 Järvelin, Marjo-Riitta YR 2007 UL http://thorax.bmj.com/content/62/5/396.abstract AB Background: While some studies suggest that poor fetal growth rate, as indicated by lower birth weight, is associated with poor respiratory function in childhood, findings among adults remain inconsistent. A study was undertaken to determine the association between early growth and adult respiratory function. Methods: A longitudinal birth cohort study was performed of 5390 men and women born full term and prospectively followed from the fetal period to adulthood. Weight at birth and infancy were recorded, and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were assessed by standard spirometry at age 31 years. Results: Adult FEV1 and FVC increased linearly with higher birth weight in both men and women with no apparent threshold. After adjustment for sex, adult height and other potential confounders operating through the life course, every 500 g higher birth weight was associated with a higher FEV1 of 53.1 ml (95% CI 38.4 to 67.7) and higher FVC of 52.5 ml (95% CI 35.5 to 69.4). These positive associations persisted across categories of smoking, physical activity and body mass index, with the lowest respiratory function noted among those with lower birth weight who were smokers, led a sedentary lifestyle or were overweight. Weight gain in infancy was also positively associated with adult lung function. Conclusion: Birth weight is continuously and independently associated with adult respiratory function. It is plausible that poor growth in early life may restrict normal lung growth and development, which could have long-term consequences on lung function later in life.