TY - JOUR T1 - When is it too EARLY to start bosentan in pulmonary arterial hypertension? JF - Thorax JO - Thorax SP - 865 LP - 865 VL - 63 IS - 10 AU - F Magdy Y1 - 2008/10/01 UR - http://thorax.bmj.com/content/63/10/865.abstract N2 - Pulmonary arterial hypertension is a debilitating progressive disease which eventually leads to right heart failure and death. Although observational studies indicate that early treatment initiation might be advantageous, previous clinical trials only looked at the use of bosentan (dual endothelin receptor antagonist) in patients with advanced symptomatic states (WHO functional class III and IV).The EARLY trial … ER -