TY - JOUR T1 - Using molecular markers as a means of predicting prognosis and outcomes in the treatment of lung cancer JF - Thorax JO - Thorax SP - 535 LP - 535 VL - 62 IS - 6 AU - Jenny Cosgrove Y1 - 2007/06/01 UR - http://thorax.bmj.com/content/62/6/535.abstract N2 - ▴ Zheng Z, Chen T, Li X. DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. NEJM2007;356:800–08.OpenUrlCrossRefPubMedWeb of Science This study evaluated the potential association between the expression of two specific proteins and treatment outcomes of patients with early non-small-cell lung cancer. Increased expression of the gene RRM1 (regulatory subunit of ribonucleotide reductase) has been shown to reduce metastases, inhibit development of lung tumours and prolong survival. Similar data have been shown for ERCC1 (excision repair … ER -