RT Journal Article
SR Electronic
T1 Systemic inflammation and lung function in young adults
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 1064
OP 1068
DO 10.1136/thx.2006.076877
VO 62
IS 12
A1 Hancox, Robert J
A1 Poulton, Richie
A1 Greene, Justina M
A1 Filsell, Susan
A1 McLachlan, Christene R
A1 Rasmussen, Finn
A1 Taylor, D Robin
A1 Williams, Michael J A
A1 Williamson, Avis
A1 Sears, Malcolm R
YR 2007
UL http://thorax.bmj.com/content/62/12/1064.abstract
AB Background: Impaired lung function is associated with systemic inflammation and is a risk factor for cardiovascular disease in older adults. It is unknown when these associations emerge and to what extent they are mediated by smoking, chronic airways disease, and/or established atherosclerosis. We explored the association between the forced expiratory volume in one second (FEV1) and the systemic inflammatory marker C-reactive protein (CRP) in young adults.Methods: Associations between spirometric lung function and blood CRP were assessed in a population based birth cohort of approximately 1000 New Zealanders at ages 26 and 32 years. Analyses adjusted for height and sex to account for differences in predicted lung function and excluded pregnant women.Results: There were significant inverse associations between FEV1 and CRP at both ages. Similar results were found for the forced vital capacity. These associations were similar in men and women and were independent of smoking, asthma, and body mass index.Conclusions: Reduced lung function is associated with systemic inflammation in young adults. This association is not related to smoking, asthma, or obesity. The reasons for the association are unexplained, but the findings indicate that the association between lower lung function and increased inflammation predates the development of either chronic lung disease or clinically significant atherosclerosis. The association between poor lung function and cardiovascular disease may be mediated by an inflammatory mechanism.