TY - JOUR T1 - Is there a relationship between <em>Mycobacterium tuberculosis</em> strain type and TB paradoxical reaction? JF - Thorax JO - Thorax SP - 706 LP - 707 DO - 10.1136/thx.2005.044321 VL - 60 IS - 8 AU - F M R Perrin AU - R A M Breen AU - M C I Lipman AU - R J Shorten AU - S H Gillespie AU - T D McHugh Y1 - 2005/08/01 UR - http://thorax.bmj.com/content/60/8/706.2.abstract N2 - Paradoxical reaction (PR) in tuberculosis (TB) is defined as transient worsening of symptoms and signs or the appearance of new lesions after beginning appropriate anti-tuberculosis chemotherapy. Recent studies suggest that PR occurs in 10–35% of patients. It is more common and more severe in HIV co-infected individuals with disseminated disease.1 PR is thought to be an immune mediated phenomenon but the reasons for its occurrence are unknown.1 Infection by Mycobacterium tuberculosis (MTB) results in highly variable outcomes between individuals. The characterisation of MTB strains by molecular typing techniques suggests this may be a reflection of the infecting organism, as well as host response and environmental factors. MTB strains with distinct genotypes have been shown to evoke different immunopathological events in mouse models2 and variable clinical manifestations … ER -