TY - JOUR T1 - α<sub>1</sub>-Antitrypsin genotype unaffected by age JF - Thorax JO - Thorax SP - 258 LP - 259 VL - 60 IS - 3 AU - M Dahl AU - B G Nordestgaard Y1 - 2005/03/01 UR - http://thorax.bmj.com/content/60/3/258.abstract N2 - In a recent otherwise excellent editorial in Thorax,1 Dr Seersholm indicated that our previous results on the decline in forced expiratory volume in 1 second (FEV1) based on the Copenhagen City Heart Study2 are biased. We disagree, and rather believe that our study of the general population is prone to less bias than case-control or family based studies. Dr Seersholm argues that, because we genotyped study participants after measurement of FEV1 in 1976–8, 1981–4, and 1991–4, our results are biased.1 Certainly, if conventional risk factors are measured after development of disease, the disease might be the cause of the risk … ER -